BI-4659 [CAS 894784-05-5]

BI-4659 (Compound 47i) is a TGF-β type I receptor (TGF-βRI) (Alk5) inhibitor with an IC50 of 19 nM. BI-4659 also inhibits (IC50: 99 nM) and significantly blocks TGFβRI-mediated phosphorylation of Smad2/3 with low cross-reactivities within the human kinome. BI-4659 can be used for fibrotic diseases like idiopathic pulmonary fibrosis (IPF) and cancers research[1].

[894784-05-5]

C27H28N4O2

440.54

CN(C)CC(C=C1)=CC=C1N/C(C2=CC=CC=C2)=C3C4=CC=C(C(NCC)=O)C=C4NC/3=O

PDGFR; TGF-beta/Smad; TGF-β Receptor

ALK5; PDGFRα

Room temperature