BI 7446 [CAS 2767011-00-5]

BI 7446 is a cyclic dinucleotide (CDN) -based potent and selective stimulator of interferon genes (STING) agonist. BI 7446 can activate all five STING variants in cells and induce tumor-specific immune-mediated tumor rejection. BI 7446 can be used for immuno-oncology research[1].

[2767011-00-5]

C20H22FN9O10P2S2

693.52

O[C@H]1[C@@H](O2)[C@H](N3C(C=NNC4=O)=C4N=C3)O[C@@H]1CO[P@](O[C@H]5[C@@H](F)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]5CO[P@]2(S)=O)(S)=O

STING

10 mM in DMSO

Room temperature