BI1543673

BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. BI1543673 can reduce the inflammatory response stimulated by TLR4 and TLR7/8 in human lung tissue. BI1543673 can decrease inflammatory signaling in a mouse model of lung inflammation induced by LPS[1].

C29H37N7O2

515.65

CC1=CN2N=CC(C(NC3=NC4=C(N3CC(C)(O)C)C=CC([C@H]5CC[C@H](CC5)N6CCCC6)=C4)=O)=C2N=C1

IRAK; Toll-like Receptor (TLR)

TLR4; TLR7; TLR8

Room temperature