BiKEAP1

BiKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models[1].

C61H60N8O18S4

1321.43

O=C(NC1=CC=C(S(=O)(NC2=C3C=CC=CC3=C(N(CC(O)=O)S(=O)(C4=CC=C(OC)C=C4)=O)C=C2)=O)C=C1)CCC(NCCCNC(CCC(NC5=CC=C(S(=O)(NC6=C7C=CC=CC7=C(N(CC(O)=O)S(=O)(C8=CC=C(OC)C=C8)=O)C=C6)=O)C=C5)=O)=O)=O

Keap1-Nrf2

99.44

10 mM in DMSO

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature