Bisindolylmaleimide X [CAS 131848-97-0]

Bisindolylmaleimide X (Ro 31-8425, BIM-X) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X can be used for research on the immune system and cardiovascular diseases[1][2][3].

[131848-97-0]

C26H24N4O2

424.49

NCC1CCN2C(C1)=C(C3=C2C=CC=C3)C4=C(C5=CN(C)C6=CC=CC=C65)C(NC4=O)=O

CDK; PKC

Room temperature

H301-H311-H331-H341

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501