BMS-223131 [CAS 275375-69-4]

BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme (IC50 = 1.7 μM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2, CYP2C19, CYP2D6, and CYP3A4. BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K+ efflux to hyperpolarize the cell membrane and reducing Ca2+ influx. BMS-223131 can be used for the research of neurological disease, such as stroke[1].

[275375-69-4]

C18H13ClF3NO3

383.75

O=C1NC2=C(C=C(C(F)(F)F)C=C2)C(C3=CC(Cl)=CC=C3O)=C1CCO

Cytochrome P450; Potassium Channel

CYP1A2; CYP2C19; CYP2C9; CYP2D6; CYP3A4

Room temperature