BMS-681 [CAS 847998-92-9]

BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2) . BMS-681 restricts the movement of the extracellular end of TM6 by stabilizing TM7. TM7 and TM6 are the main components of the orthosteric binding site. BMS-681 can be used to study inflammatory neurodegenerative diseases and cancer[1].

[847998-92-9]

C26H36F3N5O

491.59

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CCR

Room temperature