BMS-751324 [CAS 948842-66-8]

BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA) . BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model[1].

[948842-66-8]

C32H35N6O10P

694.63

CC1=CC=C(C(NC2CC2)=O)C=C1NC3=NC=NN4C3=C(C)C(C(N(C(OCOC(CC5=CC=C(OP(O)(O)=O)C=C5)=O)=O)CCC)=O)=C4

P38 MAPK; TNF Receptor

10 mM in DMSO

Room temperature