(-) -BO 2367 [CAS 145902-81-4]

(-) -BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-) -BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-) -BO 2367 is a potent antitumor agent[1].

[145902-81-4]

C21H22ClF2N3O3

437.87

FC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](CC=C[C@H]5N)([H])C4)=O)C(O)=O.Cl

Bacterial; Topoisomerase

Topo II

Room temperature