Boc-PEG4-Val-Cit-PAB-OH [CAS 2055024-54-7]
Boc-PEG4-Val-Cit-PAB-OH [CAS 2055024-54-7]
SKU:QM-0054726-01
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Product Details
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Description
Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.
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CAS Number
[2055024-54-7]
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Molecular Formula
C34H58N6O11
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Molecular Weight
726.86
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Smiles
CC(C)(C)OC(NCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)CO)=O)=O)=O)=O
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Target
ADC Linker
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319
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Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
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Boc-PEG4-Val-Cit-PAB-OH [CAS 2055024-54-7]
Boc-PEG4-Val-Cit-PAB-OH is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.