Boerelasin E

Boerelasin E is the first cytochalasan possessing a cis-configured Δ21 (22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin E exhibits antiproliferative activity against MCF-7 cells (IC50=20.52 μM) more potent than cisplatin. Boerelasin E inhibits the complete cell division of MCF-7 cells by arresting them in the G2/M phase and inducing apoptosis[1].

C29H35NO5

477.59

C=C1[C@@H](O)[C@@](/C=C/C[C@H](C)CCCC(/C=C\2)=O)([H])[C@]([C@@]3([H])[C@@H]1C)(OC2=O)C(N[C@H]3CC4=CC=CC=C4)=O

Apoptosis

Room temperature