Bortezomib (GMP)
Bortezomib (GMP)
SKU:QM-0002546
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Product Details
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Description
Bortezomib (GMP) (PS-341 (GMP) ) is Bortezomib produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM)[2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) [7].
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Molecular Formula
C19H25BN4O4
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Molecular Weight
384.24
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Smiles
OB(O)[C@H](CC(C)C)NC([C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O
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Target
Apoptosis; Autophagy; NF-κB; Proteasome; TREM receptor
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Shipping Conditions
Room temperature
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Bortezomib (GMP)
Bortezomib (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.