Bosutinib-d8

Bosutinib-d8 is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[1][2].

C26H21D8Cl2N5O3

538.5

CN1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])CCCOC2=C(C=C3C(NC4=CC(OC)=C(C=C4Cl)Cl)=C(C=NC3=C2)C#N)OC

Autophagy; Bcr-Abl; Isotope-Labeled Compounds; Src

99

10 mM in DMSO

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature