BRD-K20733377 [CAS 452350-43-5]

BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide -induced IMR-90 senescent cell with an IC50 of 10.7 μM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1].

[452350-43-5]

C23H18N4O3S

430.48

O=C(C1=CC=C(C=C1)C2=CC=CC=C2)NC3=CC=C(C=C3)S(=O)(NC4=NC=CC=N4)=O

Bcl-2 Family

10mM

99.5

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature