BRD4/CK2-IN-1 [CAS 2756851-99-5]

BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC) [1]

[2756851-99-5]

C29H30ClN5O5

564.03

O=C1C2=C(OC)C=C(OC)C=C2N=C(C3=CC=C(OCC(NC4=CC(Cl)=C(N5CCN(C)CC5)C=C4)=O)C=C3)N1

Apoptosis; Autophagy; Casein Kinase; Epigenetic Reader Domain

BRD4; CK2

98.21

DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature