BRD4/FKBP12 degrader-1

BRD4/FKBP12 degrader-1 (a1d) is a BRD4/FKBP12 degrader with anti-cancer activity (BRD4 ligand: HY-78695, FKBP12 ligand: HY-176501, linker: HY-140212).

C47H50Cl3N11O6S2

1035.46

O=C(NCCOCCN1C=C(COC[C@@H]2CN(C([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)[C@@H]2CCC3)=O)CC5=NC=CC=C5)N=N1)C[C@@H]6N=C(C7=CC=C(Cl)C=C7)C8=C(SC(C)=C8C)N9C6=NN=C9C

Epigenetic Reader Domain; FKBP

FKBP12

Room temperature