BRD4/NAMPT-IN-1 [CAS 3049218-28-9]
BRD4/NAMPT-IN-1 [CAS 3049218-28-9]
SKU:QM-0153175-01
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Product Details
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Description
BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4) ) . BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects[1].
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CAS Number
[3049218-28-9]
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Molecular Formula
C30H30ClN7O2S
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Molecular Weight
588.12
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Smiles
ClC(C=C1)=CC=C1C2=N[C@@H](CC(NCCCNC(/C=C/C3=CN=CC=C3)=O)=O)C4=NN=C(C)N4C5=C2C(C)=C(C)S5
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Target
Epigenetic Reader Domain; NAMPT
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Isoform
BRD4
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Purity
99.45
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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BRD4/NAMPT-IN-1 [CAS 3049218-28-9]
BRD4/NAMPT-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.