BRD9 Degrader-1

BRD9 c-1 (Compound 13-7) is a PROTAC BRD9 degrader[1]. BRD9 Degrader-1 has a micromolar binding affinity for BRD9 and a nanomolar affinity for the BRD9-VCB ternary complex. BRD9 Degrader-1 induces BRD9 proteasome degradation in HEK293T cells, which can be reversed by MLN4924. (Blue: VH032-cyclopropane-F (HY-125905) ; Black: linker (HY-W763939) ; Pink: HY-168695).

C49H65FN12O7S2

1017.25

[H][C@]1([C@@H](CCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC([C@H]4N(C([C@H](C(C)(C)C)NC(C5(CC5)F)=O)=O)C[C@@H](C4)O)=O)[C@]1([H])C6)CN6C7=NC(N(C(C)C)CCNC(C)=O)=NC(N8CC(C8)OC9=NC=CS9)=N7

Epigenetic Reader Domain; PROTACs

10 mM in DMSO

Room temperature