BRPF1B/TRIM24-IN-1 [CAS 1242907-48-7]

BRPF1B/TRIM24-IN-1 (compound 34) is a potent TRIM24/BRPF1/BRPF2 inhibitor, with IC50 values of 0.43, 0.34, 1.75 μM, respectively. BRPF1B/TRIM24-IN-1 binds the TRIM24 bromodomain with a KD of 222 nM and has a KD for the BRPF1 bromodomain of 137 nM and for BRD1 of 1130 nM[1].

[1242907-48-7]

C24H25N3O7S

499.54

O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC=C(OC)C=C3)C=C(N4C)C(N(C)C4=O)=C2)=O

Epigenetic Reader Domain

BRPF1; BRPF2

Room temperature