BSJ-5-63 [CAS 2519823-37-9]

BSJ-5-63 is a potent CDK12, CDK7, CDK9 PROTAC degrader. BSJ-5-63 BSJ-5-63 decreases the protein expression of CDK12, CDK7, CDK9, RNAPII, Cyclin K. BSJ-5-63 decreases the mRNA expression of BRCA1, BRCA2. BSJ-5-63 shows anticancer activity and has the potential for the research of prostate cancer (Pink: ligand for target protein ; black: linker (HY-W140827) ; Blue: E3 ligase ligand (HY-112078) ).

[2519823-37-9]

C52H74ClN9O6S2

1020.78

O=S(C1=CC=CC=C1NC2=NC(N[C@H]3CN(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)CCC3)=NC=C2Cl)(C(C)C)=O

CDK; PROTACs

CDK12; CDK7; CDK9

99.97

DMSO : 100 mg/mL (ultrasonic)

Store at room temperature 3 years

Room Temperature