BSO-07

BSO-07 is a ROS/JNK activator with significant anticancer effects, having an IC50 value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer[1].

C24H27ClFN3O

427.94

ClC1=CC=C(N2CCN(CC3=NO[C@@](CCC4)([H])[C@@]4([H])[C@H]3C5=CC=CC=C5)CC2)C(F)=C1

JNK; Reactive Oxygen Species (ROS)

Room temperature