BT-O2C [CAS 3055107-34-8]

BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines (IC50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5). BT-O2C can be used for research on cancer. (Pink: p300 Ligand ; Blue: CRBN Ligand (HY-W023573) ; Black: Linker; CRBN Ligand+Linker (HY-174869) ).

[3055107-34-8]

C48H48F5N9O8

973.94

O=C(N(CC1=CC=C(F)C=C1)[C@@H](C)C(F)(F)F)CN(C(N[C@]23C[C@@H](F)C4=C3C=CC(C5=CN(CC(NCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)N=C5)=C4)=O)C2=O

Epigenetic Reader Domain; Histone Acetyltransferase; PROTACs

CBP/p300; Cereblon

Room temperature