BTK-IN-26 [CAS 2762043-61-6]

BTK-IN-26 (compound 18) is a potent inhibitor of Bruton's tyrosine kinase (BTK) and its C481 mutant, with IC50 values of 0.7 and 0.8 nM for BTK and BTK C481S, respectively. BTK-IN-26 can be used for cancer and autoimmune diseases research[1].

[2762043-61-6]

C27H26D3FN6O3

507.57

NC1=NC=NN2C([C@@H]3CC[C@H](CC3)CO)=NC(C4=CC=C(C=C4)CNC(C5=C(C=CC(F)=C5)OC([2H])([2H])[2H])=O)=C12

Btk

10 mM in DMSO

Room temperature