BTK-IN-44

BTK-IN-44 (Compound 10) is a potent noncovalent inhibitor of Bruton’s tyrosine kinase (BTK) with an IC50 value of 24.7 nM. BTK-IN-44 interferes with signaling pathways of B cell malignancies, showing antitumor effects in lymphoma cells. BTK-IN-44 is promising for research of B cell malignancies (such as lymphoma) [1].

C30H26N4O3

490.55

CC1=C(NC(C2=CC3=C(C=CC=C3)N2)=O)C=CC=C1C4=CC=C5C(NC6=CC(C(O)(C)C)=CC=C6N54)=O

Btk

Room temperature