BuChE-IN-16

BuChE-IN-16 (Compound 6a) is an orally active, BBB-permeable, and selective BuChE inhibitor with an IC50 of 0.33 μM. BuChE-IN-16 has anti-inflammatory and neuroprotective effects. BuChE-IN-16 can improve the cognitive function of zebrafish with Alzheimer's disease (AD) and alleviate memory impairment in mice induced by Scopolamine. BuChE-IN-16 can be used for the research of AD[1].

C16H22N2O3

290.36

O=C(N1CCCCC1)C2=CC(OC(N(C)CC)=O)=CC=C2

Cholinesterase (ChE)

BChE

Room temperature