C-ABL-IN-2 [CAS 2574593-54-5]

C-ABL-IN-2 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-2 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2020260871A1, compound 25) [1]. c-ABL-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

[2574593-54-5]

C21H20N4O

344.41

O=C(NC1=CN(C(C)C)C=N1)C2=CC=C(C)C(C#CC3=CC=CN=C3)=C2

Bcr-Abl

10 mM in DMSO

Room temperature