C-ABL-IN-3 [CAS 2626934-64-1]

C-ABL-IN-3 is a potent inhibitor of c-Abl. Activation of c-Abl has been implicated in various diseases, notably cancer. c-ABL-IN-3 has the potential for the research of neurodegenerative diseases (amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) and cancer (extracted from patent WO2021048567A1, compound 50) [1].

[2626934-64-1]

C17H11F3N4O3

376.29

O=C(C(C=C1)=CN(C2=CN=CN=C2)C1=O)NC3=CC=C(OC(F)(F)F)C=C3

Bcr-Abl

10 mM in DMSO

Room temperature