C-ABL-IN-5

C-ABL-IN-5 is a selective c-Abl inhibitor with neuroprotective effects. c-ABL-IN-5 has blood-brain barrier penetrability, metabolic stability and good pharmacokinetic properties. When c-ABL-IN-5 is labeled with [18F] (compound [18F]3), it can be used as a tracer to evaluate disease-modifying efficacy by complementary positron emission tomography (PET) . c-ABL-IN-5 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD) [1].

C19H17F2N3O

341.35

O=C(NC1=CN2C=C(C=CC2=N1)C3=CC=CC=C3CCF)[C@H]4[C@H](C4)F

Bcr-Abl

10 mM in DMSO

Room temperature