C-ABL-IN-6

C-ABL-IN-6 (compound A6) is a c-ABL inhibitor with IC50 value of 16.6 nM. c-ABL-IN-6 displays higher neuroprotective effects against SH-SY5Y cell death induced by MPP+. c-ABL-IN-6 can be used for the research of neurodegenerative disorder[1].

C27H21F3N6O2

518.49

CC1=CC=C(C(NC2=CC(C(F)(F)F)=CC(C3=CN(C)N=C3)=C2)=O)C=C1NC(C4=CN=C5C(C=CN5)=C4)=O

Bcr-Abl

Abl

10 mM in DMSO

Room temperature