C-Kit-IN-5-1 [CAS 1003311-62-3]

C-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].

[1003311-62-3]

C23H17N5O2

395.41

O=C1C(C2=CC3=CN=C(N)N=C3C=C2)=C(C)C=CN1C4=CC=C(C5=NC=CO5)C=C4

C-Kit

98.03

DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature