C-Kit-IN-9

Kit-IN-9 (Compound D9) is an inhibitor of c-Kit. c-Kit-IN-9 inhibits the inflammatory responses in J774A.1, RAW264.7, MPMs cells and lung tissues by blocking the activation of the NF-κB pathway induced by LPS. Meanwhile, c-Kit-IN-9 exhibits good anti-inflammatory activities in acute lung injury and sepsis mouse models. c-Kit-IN-9 can be used in the research of acute lung injury and related inflammatory diseases[1].

C34H25FN4O4S

604.65

O=C(C1=CC(OC2=CC=C(C=C2)NC(C3=CN(C4=C(C3=O)C=CC=C4)C5=CC=C(C=C5)F)=O)=CC=N1)NCCC6=CC=CS6

C-Kit

Room temperature