C-Met-IN-24

C-Met-IN-24 (compound 3g) is a dual-target inhibitor of STAT-3 ([1]=4.7 μM) and c-MET ([1]=12.67 μM) with anticancer activity. c-Met-IN-24 arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells. c-Met-IN-24 can be used in the study of central nervous system cancers[1].

C20H15ClN4O4S

442.88

COC1=CC=CC2=C1OC(C(C3=CSC(NNC(NC4=CC=C(Cl)C=C4)=O)=N3)=C2)=O

Apoptosis; c-Met/HGFR; STAT

Met; STAT3

Room temperature