Cabotegravir (sodium) [CAS 1051375-13-3]

Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs) . Cabotegravir sodium can be used to research AIDS[1][2].

[1051375-13-3]

C19H16F2N3NaO5

427.33

FC1=C(CNC(C2=CN3C(C(N([C@@H](C)CO4)[C@@]4([H])C3)=O)=C(O[Na])C2=O)=O)C=CC(F)=C1

HIV; HIV Integrase; OAT

99.87

DMSO : 6.25 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture)

Room Temperature

H400, H410

H400, H410