CALP2 [CAS 261969-04-4]

CALP2 is a calmodulin (CaM) antagonist ((Kd of 7.9 µM) ) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].

[261969-04-4]

C68H104N14O13S

1357.7

O=C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](C(C)C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

Calmodulin

10 mM in DMSO

Room temperature