Canagliflozin-d6

Canagliflozin-d6 is the deuterium labeled Canagliflozin[1]. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[2].

C24H19D6FO5S

450.55

O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1C2=CC(C([2H])(C3=CC=C(S3)C4=C(C([2H])=C(C([2H])=C4[2H])F)[2H])[2H])=C(C=C2)C)CO)O)O

SGLT

SGLT2

10 mM in DMSO

Room temperature