Carbenoxolone-d4
Carbenoxolone-d4
SKU:QM-0080141
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Product Details
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Description
Carbenoxolone-d4 is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties[3]. Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease[2]. Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD[1]. Carbenoxolone is small molecule Pannexin1 (Panx1, is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop[4].Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself[6].
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Molecular Formula
C34H46D4O7
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Molecular Weight
574.78
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Smiles
C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O)=O)C)C)=O)([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)C)([H])CC1)C
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Target
11β-HSD; Amyloid-β; HIV
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Carbenoxolone-d4
Carbenoxolone-d4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.