CARM1-IN-4 [CAS 2878481-07-1]

CARM1-IN-4 (compound 11f) is a potent CARM1 inhibitor with IC50s of 9 nM and 56 nM for CARM1 and PRMT1, respectively. CARM1-IN-4 displays significant anti-proliferative effects on colorectal cancer cell lines. CARM1-IN-4 effectively inhibits the methyltransferase activity of CARM1 and prevents methylation of downstream proteins. CARM1-IN-4 induces apoptosis and shows antitumor activity[1].

[2878481-07-1]

C24H42N2O4

422.6

CN(C[C@@H](O)CNC)CC1=CC=CC=C1OC2CCC(COCC)(COCC)CC2

Apoptosis; Histone Methyltransferase

PRMT1; PRMT3; PRMT5; PRMT6; PRMT8

10 mM in DMSO

Room temperature