Cath-L-dBET1

Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study[1].

C58H66ClN11O11S

1160.73

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(NCCCCN(C(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)CC7=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C7)=O)=C(S1)N8C3=NN=C8C

Epigenetic Reader Domain; PROTACs

Room temperature