Catharanthine [CAS 2468-21-5]

Catharanthine ((+) -3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC) . Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR) . Catharanthine has anti-cancer activity[1][2].

[2468-21-5]

C21H24N2O2

336.43

O=C([C@@]12C3=C(CC[N@](C4)[C@]1([H])C(CC)=C[C@@]4([H])C2)C5=CC=CC=C5N3)OC

Calcium Channel

L-type calcium channel

10mM

99.65

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302

H302