Cathepsin C-IN-5 [CAS 2825567-97-1]

Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases) . Cathepsin C-IN-5 shows anti-inflammatory activity[1].

[2825567-97-1]

C21H17ClN6OS

436.92

CC(NC1=CC=CC(NC2=C(C=NC(NC3=NC=C(C=C3)C4=CSC=C4)=N2)Cl)=C1)=O

Cathepsin

Cathepsin C

95.7

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature