Cathepsin L-IN-2 [CAS 108005-94-3]

Cathepsin L-IN-2 ((Rac) -Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK , with an IC50 of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.

[108005-94-3]

C27H27FN2O4

462.51

O=C(OCC1=CC=CC=C1)NC(CC2=CC=CC=C2)C(NC(CC3=CC=CC=C3)C(CF)=O)=O

Cathepsin

Cathepsin L

98.02

DMSO : 42.5 mg/mL (ultrasonic)

-20°C (Powder, sealed storage, away from moisture and light)

Blue Ice