CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].
Molecular Formula
C16H21BrN4O3S2
Molecular Weight
461.4
Smiles
BrC1=CC=C(C2=NNC(C(NCCCSSCCN)=O)=C2)C=C1.OC=O
Target
Bcl-2 Family
Concentration
10mM
Purity
99.54
Solubility
DMSO : 125 mg/mL (ultrasonic)
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)