CBP-501 (acetate)

CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser216-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC50 values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer[1][2].

C86H122F5N29O17.xC2H4O2

N=C(N)NCCC[C@H](C(O)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCC(N)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CC1CCCCC1)NC([C@@H](CC2=C(F)C(F)=C(F)C(F)=C2F)NC([C@@H](CO)NC([C@@H](CC3=CNC4=CC=CC=C34)NC([C@@H](CO)NC([C@@H](CC5=CC=C(C(C6=CC=CC=C6)=O)C=C5)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O.[x]

Calmodulin; Checkpoint Kinase (Chk) ; MAP3K; MAPKAPK2 (MK2)

Chk1; Chk2; MAP3K7/TAK1

99.75

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Blue Ice