CCZ01048

CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma[1].

C71H105N21O16

1508.72

O=C(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CCCCNC4=O)C(N)=O)=O)=O)CCCNC(N)=N)=O)=O)CC5=CN=CN5)[C@H](C4)NC([C@H](CCCC)NC(CN6CCC(NC(CN7CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC7)=O)CC6)=O)=O

Melanocortin Receptor

MC1R

10 mM in DMSO

Room temperature