CD28-IN-1 [CAS 1465291-19-3]

CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48 μM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-γ, IL-2 and TNF-α) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research[1].

[1465291-19-3]

C16H17N3O4

315.32

O=C1N(C)C2=CC=CC(C(OCCC3=C(C)NN=C3C)=O)=C2O1

CD28; IFNAR; Interleukin Related; TNF Receptor

IL-2

Room temperature