Cefsulodin (sodium hydrate) [CAS 1426397-23-0]

Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC50 value of 16 μM[1][2][3][4].

[1426397-23-0]

C22H19N4O8S2.Na.XH2O

[O-]C(C1=C(C[N+]2=CC=C(C(N)=O)C=C2)CS[C@@]([C@@H]3NC([C@@H](C4=CC=CC=C4)S(=O)(O[Na])=O)=O)([H])N1C3=O)=O.[F,Cl,Br,I].O

Antibiotic; Bacterial

10 mM in DMSO

Room temperature

H317-H334

P261-P272-P280-P284-P302+P352-P304+P340-P362+P364-P501