Cephaeline [CAS 483-17-0]

Cephaeline ((-) -Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy[1][2][3][4].

[483-17-0]

C28H38N2O4

466.61

OC1=CC2=C([C@@H](C[C@@H]3[C@@H](CC)CN4CCC5=CC(OC)=C(OC)C=C5[C@]4([H])C3)NCC2)C=C1OC

Ferroptosis; Filovirus; Flavivirus; Keap1-Nrf2; Reactive Oxygen Species (ROS)

EBOV

99.77

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 33.33 mg/mL (ultrasonic)

4°C (Powder, protect from light)

Room Temperature

H300, H330

H300, H330