CF53 [CAS 1808160-52-2]

CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo[1].

[1808160-52-2]

C24H25N7O2

443.5

COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1

Epigenetic Reader Domain; Histone Acetyltransferase

BRD2; BRD3; BRD4; BRDT; CBP/p300; CECR2; TIP60

99.81

DMSO : 110 mg/mL (ultrasonic)

-20°C (Powder, stored under nitrogen)

Blue Ice