ChE/Aβ1-42-IN-1 [CAS 2761149-22-6]

ChE/Aβ1-42-IN-1 (compound 28) is a potent ChE and Aβ1-42 aggregation inhibitor with IC50s of 0.062, 0.767 and 1.227 µM for AChE, BuChE and Aβ1-42 aggregation, respectively. ChE/β1-42-IN-1 shows excellent BBB penetration. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer's agent[1].

[2761149-22-6]

C19H24N2O3

328.41

COC1=C(C=C2C(N=C3CCCCC3=C2N4CCOCC4)=C1)OC

Amyloid-β; Cholinesterase (ChE)

AChE

10 mM in DMSO

Room temperature