Chem-0199

Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer[1].

C13H18N2O2

234.29

CC1(C)N(O)[C@H](C2=CC=CC=C2)[N+]([O-])=C1CC

Akt; DNA/RNA Synthesis; PD-1/PD-L1

Room temperature